A mathematical model showing the potential of vitamin c to boost the innate immune response

There has been much debate about the role Vitamin C plays in the innate immune response, and if it has the potential to be used as a drug to combat conditions in which the immune system is compromised, from the common cold to cystic fibrosis. Here, the author creates a basic model of the innate response, capturing the dynamics among phagocytic cells, host cells, foreign virus/bacteria, and Vitamin C. Through mathematical simulations, the author concludes that Vitamin C can be used as a stand-alone drug to eradicate a viral/bacterial infection if given constant infusions. If this is not possible due to other side effects that may harm the patient, Vitamin C may be used in quick succession with another anti-bacterial/anti-viral medication to aid the patient. This, moreover, could help minimize the amount of side effects of the anti-bacterial/anti-viral drug and slow down bacterial evolution. Finally, the author modifies the system to simulate cases of renal failure, acute lung injury, liver damage, chronic granulomatous disease, and the Chédiak-Higashi syndrome, showing how Vitamin C can help individuals with these diseases.