INSULIN RESISTANCE AND BODY MASS INDEX WITH REGARD TO VARIOUS THYROID STIMULATING HORMONE REFERENCE INTERVALS

Aksoy, Neval and Yeler, Mustafa Taner and Ayan, Nilhan Nurlu and Ozkeskin, Ali and OZKAN, ZEYNEP and Serin, Ozden N (1969) INSULIN RESISTANCE AND BODY MASS INDEX WITH REGARD TO VARIOUS THYROID STIMULATING HORMONE REFERENCE INTERVALS. Pakistan Journal of Medical Sciences, 31 (6). ISSN 1681-715X

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Abstract

Objective: Previous studies have shown an association between thyroid function and insulin resistance and obesity. We compared insulin resistance and body mass index (BMI) in patients with normal TSH levels (2.5–4.2 µIU/mL), patients diagnosed with subclinical hypothyroidism, and healthy control subjects.

Methods: The study included 104 subjects and was conducted at the Taksim Education and Research Hospital. The subjects were divided into three groups according to TSH levels: Group 1 (high-normal), TSH levels were 2.5–4.2 µIU/mL (n=33); Group 2 (subclinical hypothyroidism), TSH levels were 4.2–10 µIU/mL (n=42); and Group 3 (healthy control), TSH levels were 0.27–2.5 µIU/mL (n=29).The fT3 and fT4 levels were within normal limits in all groups. Insulin resistance and BMI were compared among groups. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to estimate insulin resistance.

Results: HOMA-IR and BMI were not significantly different among groups (p>0.05). A significant positive correlation was found between BMI and HOMA-IR in the high-normal TSH (p>0.059) and subclinical hypothyroidism (p>0.05) groups.

Conclusions: HOMA-IR and BMI are important for the assessment of diabetes and cardiovascular diseases. We found no significant difference in HOMA-IR and BMI values among the three TSH reference range groups.

Item Type: Article
Subjects: Research Asian Plos > Medical Science
Depositing User: Unnamed user with email support@research.asianplos.com
Date Deposited: 09 May 2023 10:09
Last Modified: 22 Oct 2024 04:39
URI: http://abstract.stmdigitallibrary.com/id/eprint/789

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