Polymorphisms in NF-κB pathway genes and their association with risk of lung cancer in the Chinese population

Zhang, Jing-Wei and Chen, Qiu-Sheng and Zhai, Jian-Xia and Lv, Peng-Ju and Sun, Xiao-Yan (2015) Polymorphisms in NF-κB pathway genes and their association with risk of lung cancer in the Chinese population. Pakistan Journal of Medical Sciences, 31 (6). ISSN 1681-715X

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Abstract

Objective:To investigate the association of NFKB1 -94 ins/del ATTG, NFKBIA -826C>T and NFKBIA -881A>G polymorphisms with risk of lung cancer in a Chinese population.

Methods:Genotyping of the polymorphisms were performed on 1,436 subjects (718 cases and 718 controls) by using PCR-RFLP technique, followed by DNA sequencing.

Results:We found a significant risk reduction associated with heterozygous ins/del (OR=0.705, 95% CI=0.566-0.878, P=0.002) and variant del/del (OR=0.342, 95% CI=0.221-0.528, P<0.001) genotypes of the NFKB1 polymorphism. In contrast, the heterozygous and variantgenotypes of theNFKBIA polymorphisms showed association with increased lung cancer risk (NFKBIA -826 CT,OR=1.256, 95%CI=1.004-1.572, P=0.046; TT,OR=1.773, 95% CI=1.131-2.778, P=0.013; NFKBIA -881 AG,OR=1.277, 95% CI=1.023-1.599, P=0.031; GG,OR=1.801, 95% CI=1.169-2.775, P=0.008). Several genotypic combinations of the three polymorphisms also showed significant association with lung cancer risk. The risk association of NFKB1 polymorphism remained significant when analyses were done according to gender and smoking status (P<0.05). The significance of NFKBIA risk association was not observed when gender-specific analyses were made (P>0.05), while only NFKBIA -881 GG genotype showed significant risk association among smokers when analyzed according to smoking status (P=0.032).

Conclusions: Polymorphisms in NFKB1 and NFKBIAgenes were associated with risk of lung cancer.

Item Type: Article
Subjects: Research Asian Plos > Medical Science
Depositing User: Unnamed user with email support@research.asianplos.com
Date Deposited: 10 May 2023 10:22
Last Modified: 23 Oct 2024 04:14
URI: http://abstract.stmdigitallibrary.com/id/eprint/788

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