Sadiq, Idris Zubairu and Babagana, Kamaluddeen and Danlami, Dauda and Abdullahi, Lawi Isa and Khan, Amir Riyaz (2018) Molecular Therapeutic Cancer Peptides: A Closer Look at Bovine Lactoferricin. Asian Journal of Biochemistry, Genetics and Molecular Biology, 1 (2). pp. 1-9. ISSN 2582-3698
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Abstract
Background: In spite of the progress that was recorded in the development of anticancer drugs, challenges continue to rises particularly due to resistance of the cancer chemotherapies and low sensitivity of the commercially available anticancer drugs.
Methodology: collection and review of available literatures.
Results: Bovine lactoferricin (LfcinB) is a cationic peptide with broad spectrum antimicrobial and anticancer activity. It also shows promising activity against many varieties of cancer cells including colon carcinoma cells, melanoma, fibrosarcoma, monocytic leukemic cells and neuroblastoma. It is unaffected by multidrug resistance mechanisms seen with conventional chemotherapeutic drugs, and displays a higher specificity for cancer cells versus normal cells in comparison to conventional chemotherapy.
Conclusion: LfcinB exhibit strong antitumor activity effectively penetrating cell membrane, activating caspases and induce apoptosis to cancer cells.
Item Type: | Article |
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Subjects: | Research Asian Plos > Biological Science |
Depositing User: | Unnamed user with email support@research.asianplos.com |
Date Deposited: | 22 May 2023 06:52 |
Last Modified: | 17 Oct 2024 05:03 |
URI: | http://abstract.stmdigitallibrary.com/id/eprint/695 |